Dimethyl Sulfoxide → 2-(3-bromo-2-methylphenyl)-3,4-dihydroisoquinolin-1(2H)-one

HRID 2322355Notes

Reaction equation

HRID 2322355 reaction equation
[Br:1][c:2]1[c:3]([CH3:9])[c:4]([Br:8])[cH:5][cH:6][cH:7]1.[C:10]1(=[O:20])[NH:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21.[C:21](=[O:22])([O-:23])[O-:24].[CH3:27][S:28]([CH3:29])=[O:30].[Cl:31][CH2:32][Cl:33].[Cu:34][I:35].[K+:25].[K+:26]>>[c:2]1([N:11]2[C:10](=[O:20])[c:19]3[c:14]([cH:15][cH:16][cH:17][cH:18]3)[CH2:13][CH2:12]2)[c:3]([CH3:9])[c:4]([Br:8])[cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 346812,6-DibromotolueneHCID 1508963,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 593751142-(3-bromo-2-methylphenyl)-3,4-dihydroisoquinolin-1(2H)-one

Sources & evidence

ORD record
ord-ffca843b6e774633b6d3ee4db4449f13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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