HCID 14555602, compound → HCID 14555603, compound

HRID 232256Notes

Reaction equation

HRID 232256 reaction equation
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([O:8][CH:9]([CH3:18])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>[OH-].[OH-].[Pd+2].C(O)C>[CH3:18][CH:9]([O:8][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:20][CH:19]=1)[CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1

Participants

4

Reactant 1

HCID 14555602HCID 14555602, compound

Product 1

HCID 14555603HCID 14555603, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To 50 mL ethanol is added 28 g (0.1 mol) of 4-[3-(4-nitrophenoxy)butyl]morpholine and 0.5 g of Pd(OH)2. The mixture is hydrogenated at 30 psi. Monitor the reaction by thin-layer chromatography. Upon completion remove the catalyst by suction filtration through celite. Remove the solvent in vacuo to obtain the title compound.

Workup

  1. customMonitor the reaction by thin-layer chromatography
  2. customUpon completion remove the catalyst
  3. filtrationby suction filtration through celite
  4. customRemove the solvent in vacuo

Sources & evidence

ORD record
ord-af78acccf56d4bb3a6a4bf583c6b820c
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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