HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 20031369, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 20031396 | HCID 20031396 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20031369 | HCID 20031369 | — |
Reaction Steps
To 100 mL of tetrahydrofuran is added 24.0 g (0.1 mol) of 2-[(4-pentylpiperazin-1-yl)carbonyl]cyclopropanecarboxylic acid and 13.6 g (0.4 mol) of lithium aluminum hydride. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 14 mL of H2O, 14 mL of 15% aqueous NaOH, and 42 mL of H2O. Remove the precipitate by suction filtration through celite and remove the solvent in vacuo to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851526 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-de1f78178e17401c8a8424ca6e05eeea |
| Source note | uspto-grants-1989_07 |