Tetrahydrofuran → HCID 20031369, compound

HRID 232258Notes

Reaction equation

HRID 232258 reaction equation
O1CCCC1.[CH2:6]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH:19]2[CH2:21][CH:20]2[C:22](O)=[O:23])=O)[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH2:6]([N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH:19]2[CH2:21][CH:20]2[CH2:22][OH:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH3:10]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 20031396HCID 20031396, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 20031369HCID 20031369, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 100 mL of tetrahydrofuran is added 24.0 g (0.1 mol) of 2-[(4-pentylpiperazin-1-yl)carbonyl]cyclopropanecarboxylic acid and 13.6 g (0.4 mol) of lithium aluminum hydride. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 14 mL of H2O, 14 mL of 15% aqueous NaOH, and 42 mL of H2O. Remove the precipitate by suction filtration through celite and remove the solvent in vacuo to obtain the title compound.

Workup

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the precipitate
  4. filtrationby suction filtration through celite
  5. customremove the solvent in vacuo

Sources & evidence

ORD record
ord-de1f78178e17401c8a8424ca6e05eeea
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

Loading…