(4-Chlorophenyl)acetic acid → 4-Chlorophenylacetyl chloride

HRID 232263Notes

Reaction equation

HRID 232263 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([Cl:14])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 24386Thionyl Chloride

Product 1

HCID 906924-Chlorophenylacetyl chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 100 mL of chloroform is added 4-chlorobenzeneacetic acid (17 g, 0.1 mol) and 24 g (0.2 mol) of thionyl chloride. Reflux the reaction mixture for 3 hours and remove the solvent in vacuo to give the title compound.

Workup

  1. temperatureReflux the reaction mixture for 3 hours
  2. customremove the solvent in vacuo

Sources & evidence

ORD record
ord-b5c0cdb5c426458bb669b3eccacbbbc5
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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