HCID 20031389, compound → HCID 20031360, compound

HRID 232267Notes

Reaction equation

HRID 232267 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1>C(O)(=O)C.Cl.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=3)[CH2:14][CH2:15]2)=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 20031389HCID 20031389, compound

Product 1

HCID 20031360HCID 20031360, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

In a manner similar to Preparation 3, hydrogenate 1[2-(4-chlorophenyl)ethyl]-4-[(4-nitrophenoxy)methyl]piperidine in acetic acid and hydrochloric acid over palladium on carbon to obtain the title compound.

Sources & evidence

ORD record
ord-18d0e2707be7447caf16b09fad98a316
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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