HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,2-Diethyl-4-piperidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 1-Propanamine, N-ethyl- | HCID 88398 | — |
| Reactant | 2-(Trimethylsiloxy)-1,3-butadiene | HCID 554657 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,2-Diethyl-4-piperidinone | HCID 20031315 | — |
Reaction Steps
To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851526 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-dc7eb3e1a8054954978500e3c6bd556b |
| Source note | uspto-grants-1989_07 |