反应详情

To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.

1. customMonitor the reaction by thinlayer chromatography
2. customSeparate the aqueous layer
3. extractionExtract twice with 100 mL ether
4. dry with materialdry over Na2SO4
5. filtrationFilter the drying agent
6. customevaporated the solvent in vacuo