Diethylamine → HCID 20031339, compound

HRID 232305Notes

Reaction equation

HRID 232305 reaction equation
CS(O[CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])(=O)=O.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>CO>[CH2:12]([N:14]([CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])[CH2:15][CH3:16])[CH3:13]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 20031330HCID 20031330, compound

Product 1

HCID 20031339HCID 20031339, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 10 mL of methanol add 1.75 g (2.10 mmol) of 2-[[(methylsulfonyl)oxy]methyl]cyclopropanecarbonitrile and 2.0 g (27 mmol) of diethylamine. Reflux the reaction and monitor by thin-layer chromatography. Upon completion remove the solvent in vacuo and add 50 mL methylene chloride and 50 mL sat. sodium carbonate. Separate the organic layer and dry over Na2SO4. Filter the drying agent and remove the solvent in vacuo to obtain the title compound.

Workup

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customUpon completion remove the solvent in vacuo
  4. additionadd 50 mL methylene chloride and 50 mL sat. sodium carbonate
  5. customSeparate the organic layer
  6. dry with materialdry over Na2SO4
  7. filtrationFilter the drying agent
  8. customremove the solvent in vacuo

Sources & evidence

ORD record
ord-7625e6a393a94d918be54bfae1662d0b
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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