Sodium cyanoborohydride → 1-Butyl-N-[4-(1H-imidazol-1-yl)-2-methylphenyl]-3-piperidinamine

HRID 232321Notes

Reaction equation

HRID 232321 reaction equation
[CH2:1]([N:5]1[CH2:10][CH2:9][CH2:8][C:7](=O)[CH2:6]1)[CH2:2][CH2:3][CH3:4].[N:12]1([C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[C:19]([CH3:24])[CH:18]=2)[CH:16]=[CH:15][N:14]=[CH:13]1.C([BH3-])#N.[Na+]>>[CH2:1]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([N:12]3[CH:16]=[CH:15][N:14]=[CH:13]3)=[CH:18][C:19]=2[CH3:24])[CH2:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 5003444Sodium cyanoborohydrideHCID 144502604-(1H-Imidazol-1-yl)-2-methylanilineHCID 200313451-Butyl-3-piperidinone

Product 1

HCID 200313881-Butyl-N-[4-(1H-imidazol-1-yl)-2-methylphenyl]-3-piperidinamine

Procedure

In a manner similar to Preparation 8, react 1-butyl-3-piperidinone with 4-(1H-imidazol-1-yl)-2-methylbenzenamine and sodium cyanoborohydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 8

Sources & evidence

ORD record
ord-b176b5adcf4a44529da17b4ff9b68171
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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