Dimethylformamide → tert-Butyl 4-(cyanomethyl)-4-hydroxypiperidine-1-carboxylate

HRID 2323602Notes

Reaction equation

HRID 2323602 reaction equation
[K:16][C:17]#[N:18].[O:19]=[CH:20][N:21]([CH3:22])[CH3:23].[O:1]1[CH2:2][C:3]12[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]2>>[OH:1][C:3]1([CH2:2][C:17]#[N:18])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 22135564tert-Butyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylateHCID 178511842HCID 178511842, compound

Product 1

HCID 25067313tert-Butyl 4-(cyanomethyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-a567224805fe454986354994232e7b03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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