Hydrochloric Acid → ethyl 3-(2-(3-methoxyphenyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

HRID 2324109Notes

Reaction equation

HRID 2324109 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]([B:9]([OH:10])[OH:11])[cH:6][cH:7][cH:8]1.[CH3:44][OH:45].[Cl:41][CH2:42][Cl:43].[ClH:12].[N:13]1([CH:28]2[CH2:29][CH:30]3[CH2:31][CH2:32][CH:33]([CH2:34]2)[N:35]3[C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:14][CH2:15][C:16]2([CH2:17][NH:18][CH2:19][c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]32)[CH2:26][CH2:27]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]([N:18]2[CH2:17][C:16]3([CH2:15][CH2:14][N:13]([CH:28]4[CH2:29][CH:30]5[CH2:31][CH2:32][CH:33]([CH2:34]4)[N:35]5[C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:27][CH2:26]3)[c:25]3[c:20]([cH:21][cH:22][cH:23][cH:24]3)[CH2:19]2)[cH:6][cH:7][cH:8]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 2734370(3-Methoxyphenyl)boronic acidHCID 58089661ethyl 3-(2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Product 1

HCID 58089606ethyl 3-(2-(3-methoxyphenyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Sources & evidence

ORD record
ord-c1cbb08de6fd43c783851cfc51e3996a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…