反应详情

To a solution of dimethyl ester (Step 2) (1.7 g) in 1,2-dimethoxyethane (60 ml) was added lithium hydroxide (10 ml of 2N). The reaction mixture was stirred overnight at room temperature. H2O (100 ml) was added and the 1,2-dimethoxyethane was removed under vacuo. The solution was extracted with ethylacetate (300 ml). The aqueous phase was acidified to pH 3, extracted with ethylacetate (200 ml), dried and evaporated. Flash chromatography of the residue using 5% EtOH in CH2Cl2 with 1% of acetic acid afforded the title compound.

1. customthe 1,2-dimethoxyethane was removed under vacuo
2. extractionThe solution was extracted with ethylacetate (300 ml)
3. extractionextracted with ethylacetate (200 ml)
4. customdried
5. customevaporated