Hydrochloric Acid → N1-Methyl-5-(2-(((4-(azetidin-1-yl)piperidin-1-yl)carbonyl)amino)pyridin-4-yloxy)-1H-1-indolecarboxamide

HRID 2324220Notes

Reaction equation

HRID 2324220 reaction equation
[C:6]([O:7][BH-:8]([O:9][C:10](=[O:11])[CH3:12])[O:13][C:14](=[O:15])[CH3:16])(=[O:17])[CH3:18].[CH3:20][NH:21][C:22](=[O:23])[n:24]1[cH:25][cH:26][c:27]2[cH:28][c:29]([O:33][c:34]3[cH:35][c:36]([NH:40][C:41](=[O:42])[N:43]4[CH2:44][CH2:45][C:46](=[O:49])[CH2:47][CH2:48]4)[n:37][cH:38][cH:39]3)[cH:30][cH:31][c:32]12.[Cl:50][CH2:51][Cl:52].[ClH:1].[NH:2]1[CH2:3][CH2:4][CH2:5]1.[Na+:19]>>[N:2]1([CH:46]2[CH2:45][CH2:44][N:43]([C:41]([NH:40][c:36]3[cH:35][c:34]([O:33][c:29]4[cH:28][c:27]5[cH:26][cH:25][n:24]([C:22]([NH:21][CH3:20])=[O:23])[c:32]5[cH:31][cH:30]4)[cH:39][cH:38][n:37]3)=[O:42])[CH2:48][CH2:47]2)[CH2:3][CH2:4][CH2:5]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 6344DichloromethaneHCID 10422AzetidineHCID 2724942TriacetoxyborohydrideHCID 59855857N1-Methyl-5-(2-(4-oxopiperidin-1-ylcarbonyl)amino-4-pyridyl)oxy-1H-1-indolecarboxamide

Product 1

HCID 21949261N1-Methyl-5-(2-(((4-(azetidin-1-yl)piperidin-1-yl)carbonyl)amino)pyridin-4-yloxy)-1H-1-indolecarboxamide

Sources & evidence

ORD record
ord-acc7419032ab4abdade5335220174aec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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