Hydrochloric Acid → tert-butyl (3RS,4RS)-4-(4-hydroxymethyl-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

HRID 2324270Notes

Reaction equation

HRID 2324270 reaction equation
[CH2:60]([Cl:61])[Cl:62].[CH3:63][OH:64].[ClH:53].[Na+:54].[Na+:55].[O-:56][C:57](=[O:58])[O-:59].[cH:1]1[c:2]([CH2:11][O:12][CH:13]2[CH2:14][N:15]([C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][c:22]([CH2:25][O:26][C:27]([c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)([c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[c:40]3[cH:41][cH:42][cH:43][cH:44][cH:45]3)[cH:23][cH:24]2)[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12>>[cH:1]1[c:2]([CH2:11][O:12][CH:13]2[CH2:14][N:15]([C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][c:22]([CH2:25][OH:26])[cH:23][cH:24]2)[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ion2×HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 54015520tert-butyl (3RS,4RS)-3-naphthalen-2-ylmethoxy-4-(4-trityloxymethyl-phenyl)-piperidine-1-carboxylate

Product 1

HCID 53699338tert-butyl (3RS,4RS)-4-(4-hydroxymethyl-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-eda2486243544d6880f67020f328d24e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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