反应详情

In 10 ml of methylene chloride was suspended 500 mg of methyl 2-(2,4-difluorophenylamino)5-fluoro-6-hydroxynicotinate, and to the resulting suspension were added 440 mg, of 2,4,6-trimethylbenzenesulfonyl chloride and 220 mg of triethylamine, after which the resulting mixture was subjected to reaction at room temperature for 3 hours. To this solution was added 15 ml of water, and the organic layer was separated, washed with 15 ml of water, and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and to the crystalline material thus obtained was added 15 ml of diethyl ether, after which crystals were collected by filtration to obtain 660 mg (yield 81.9%) of methyl 2-(2,4-difluorophenylamino)-5-fluoro-6-(2,4,6-trimethylbenzenesulfonyloxy)nicotinate having a melting point of 153°-155° C.

1. additionto the resulting suspension were added 440 mg
2. customthe organic layer was separated
3. washwashed with 15 ml of water
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed by distillation under reduced pressure
6. customto the crystalline material thus obtained
7. filtrationafter which crystals were collected by filtration