Dichloromethane → Pyrazolo[3,4-d]pyrimidine 11

HRID 2324520Notes

Reaction equation

HRID 2324520 reaction equation
[C:40]([CH2:41][CH2:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)(=[O:49])[Cl:50].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:51][CH2:52][Cl:53].[NH2:1][c:2]1[c:3]([O:31][CH3:32])[cH:4][c:5](-[c:8]2[n:9][n:10]([CH:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]4)[CH2:22][CH2:23]3)[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1>>[NH:1]([c:2]1[c:3]([O:31][CH3:32])[cH:4][c:5](-[c:8]2[n:9][n:10]([CH:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]4)[CH2:22][CH2:23]3)[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1)[C:40]([CH2:41][CH2:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)=[O:49]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 64801Benzenepropanoyl chlorideHCID 208170343-(4-amino-3-methoxyphenyl)-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 6539962Pyrazolo[3,4-d]pyrimidine 11

Sources & evidence

ORD record
ord-e289648698c64b419419440f002e485f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…