Methanol → N-[[3-[3-fluoro-4-[(4-hydroxypiperidin-4-yl)methoxy]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

HRID 2324607Notes

Reaction equation

HRID 2324607 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][C:14]([OH:17])([CH2:18][O:19][c:20]2[c:21]([F:37])[cH:22][c:23]([N:26]3[C:27](=[O:36])[O:28][CH:29]([CH2:31][NH:32][C:33]([CH3:34])=[O:35])[CH2:30]3)[cH:24][cH:25]2)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:38][OH:39].[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[Pd:46]>>[NH:11]1[CH2:12][CH2:13][C:14]([OH:17])([CH2:18][O:19][c:20]2[c:21]([F:37])[cH:22][c:23]([N:26]3[C:27](=[O:36])[O:28][CH:29]([CH2:31][NH:32][C:33]([CH3:34])=[O:35])[CH2:30]3)[cH:24][cH:25]2)[CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8857Ethyl AcetateHCID 23938PalladiumHCID 77232563Benzyl 4-[[4-[5-(acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]methyl]-4-hydroxypiperidine-1-carboxylate

Product 1

HCID 85421408N-[[3-[3-fluoro-4-[(4-hydroxypiperidin-4-yl)methoxy]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Sources & evidence

ORD record
ord-42d2f67dc5bc462b9ff039955c0a1c5d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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