Dichloromethane → 7a-[5-(Cyclopentylamino)-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-amine

HRID 2325002Notes

Reaction equation

HRID 2325002 reaction equation
[CH:1]1([NH:6][c:7]2[cH:8][cH:9][c:10]([F:30])[c:11]([C:13]34[N:14]=[C:15]([NH:22][C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[S:16][CH2:17][CH:18]3[CH2:19][CH2:20][O:21]4)[cH:12]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:38][CH2:39][Cl:40].[F:31][C:32]([F:33])([F:34])[C:35]([OH:36])=[O:37]>>[CH:1]1([NH:6][c:7]2[cH:8][cH:9][c:10]([F:30])[c:11]([C:13]34[N:14]=[C:15]([NH2:22])[S:16][CH2:17][CH:18]3[CH2:19][CH2:20][O:21]4)[cH:12]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178452957HCID 178452957, compound

Product 1

HCID 780034647a-[5-(Cyclopentylamino)-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-amine

Sources & evidence

ORD record
ord-50b8c53c1c30451db9504bb07170d80f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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