Methanol → 6-Chloro-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

HRID 2325079Notes

Reaction equation

HRID 2325079 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][CH3:9])[cH:10][cH:11]1.[CH3:44][OH:45].[Cl:12][c:13]1[cH:14][c:15]([N:24]([CH2:25][c:26]2[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]2)[CH:34]2[CH2:35][CH2:36]2)[c:16]2[n:17]([n:18]1)[c:19]([C:22]#[N:23])[cH:20][n:21]2.[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[Cl:12][c:13]1[cH:14][c:15]([N:24]([CH2:25][c:26]2[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]2)[CH3:34])[c:16]2[n:17]([n:18]1)[c:19]([C:22]#[N:23])[cH:20][n:21]2

Participants

5

Reactant 4

HCID 887MethanolHCID 6422Trifluoroacetic acidHCID 4854071-(4-methoxyphenyl)-N-methylmethanamineHCID 593137576-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

Product 1

HCID 866413866-Chloro-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

Sources & evidence

ORD record
ord-a41e36f948e741cc908f621e36ac69cc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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