反应详情

293.1 g (1.692 mol) of 30% strength sodium methylate solution were added to a solution of 434 g (1.692 mol) of 2,6-dichloro-4-trichloromethylpyrimidine in 1 l of 1,2-dichloroethane in the course of 11/2 hours at from 0° to 5° C. while stirring. Stirring was continued for 1 hour at from 0° to 5° C. and for 12 hours at 25° C. The reaction mixture was extracted with water and with saturated sodium chloride solution. Drying over magnesium sulfate and evaporating down gave 423 g (95% of theory) of the title compound as a virtually colorless oil of nD23 =1.5552. 1H-NMR (CDCl3) (ppm OCH3 (s/3H) 4.1; CH (s/1H) 7.25.

1. stirringStirring
2. extractionThe reaction mixture was extracted with water and with saturated sodium chloride solution
3. dry with materialDrying over magnesium sulfate
4. customevaporating down gave 423 g (95% of theory) of the title compound as a virtually colorless oil of nD23 =1.5552