Hydrochloric Acid → 8-ethyl-4-methyl-2-[(4-piperazin-1-ylphenyl)amino]-6-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 2325153Notes

Reaction equation

HRID 2325153 reaction equation
[CH2:2]([CH3:3])[n:4]1[c:5](=[O:40])[c:6](-[c:35]2[s:36][cH:37][cH:38][n:39]2)[cH:7][c:8]2[c:9]1[n:10][c:11]([NH:15][c:16]1[cH:17][cH:18][c:19]([N:22]3[CH2:23][CH2:24][N:25]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:26][CH2:27]3)[cH:20][cH:21]1)[n:12][c:13]2[CH3:14].[CH3:47][OH:48].[ClH:1].[O:41]1[CH2:42][CH2:43][O:44][CH2:45][CH2:46]1>>[CH2:2]([CH3:3])[n:4]1[c:5](=[O:40])[c:6](-[c:35]2[s:36][cH:37][cH:38][n:39]2)[cH:7][c:8]2[c:9]1[n:10][c:11]([NH:15][c:16]1[cH:17][cH:18][c:19]([N:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[cH:20][cH:21]1)[n:12][c:13]2[CH3:14]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 57606982Tert-butyl 4-(4-(8-ethyl-4-methyl-7-oxo-6-(thiazol-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl)piperazine-1-carboxylate

Product 1

HCID 161243348-ethyl-4-methyl-2-[(4-piperazin-1-ylphenyl)amino]-6-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one

Sources & evidence

ORD record
ord-67cb253c3f91485190f8e53747d65c14
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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