3-Bromopyridine → 5'-Bromo-6-cyclopropyl-4-(4-trifluoromethylphenyl)-[2,3']bipyridinyl

HRID 2325316Notes

Reaction equation

HRID 2325316 reaction equation
[BH:28]([OH:29])[OH:30].[Br:31][c:32]1[cH:33][n:34][cH:35][cH:36][cH:37]1.[Br:38][c:39]1[cH:40][c:41]([Br:42])[cH:43][n:44][cH:45]1.[CH:1]1([c:4]2[cH:5][c:6](-[c:18]3[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]3)[cH:7][c:8]([O:10][S:11]([C:12]([F:13])([F:14])[F:15])(=[O:16])=[O:17])[n:9]2)[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[cH:5][c:6](-[c:18]3[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]3)[cH:7][c:8](-[c:36]3[cH:35][n:34][cH:33][c:32]([Br:31])[cH:37]3)[n:9]2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 122863-BromopyridineHCID 61668Boronic AcidHCID 693693,5-DibromopyridineHCID 57468747Trifluoro-methanesulfonic acid 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester

Product 1

HCID 686910535'-Bromo-6-cyclopropyl-4-(4-trifluoromethylphenyl)-[2,3']bipyridinyl

Sources & evidence

ORD record
ord-595c9a0d7b774c29a0f59a7b0245f06c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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