Dichloromethane → Methyl {8-fluoro-2-[4-(4-fluorophenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate

HRID 2325480Notes

Reaction equation

HRID 2325480 reaction equation
[Cl:42][CH2:43][Cl:44].[F:1][c:2]1[c:3]([N:14]=[C:15]=[N:16][c:17]2[c:18]([O:27][CH3:28])[cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[c:4]([CH:8]=[CH:9][C:10](=[O:11])[O:12][CH3:13])[cH:5][cH:6][cH:7]1.[F:29][c:30]1[cH:31][cH:32][c:33]([N:36]2[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]2)[cH:34][cH:35]1>>[F:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[CH:8]([CH2:9][C:10](=[O:11])[O:12][CH3:13])[N:16]([c:17]1[c:18]([O:27][CH3:28])[cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]1)[C:15]([N:39]1[CH2:38][CH2:37][N:36]([c:33]3[cH:32][cH:31][c:30]([F:29])[cH:35][cH:34]3)[CH2:41][CH2:40]1)=[N:14]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 752601-(4-Fluorophenyl)piperazineHCID 72436574Methyl 3-[3-fluoro-2-[[2-methoxy-5-(trifluoromethyl)phenyl]iminomethylideneamino]phenyl]prop-2-enoate

Product 1

HCID 58823999Methyl {8-fluoro-2-[4-(4-fluorophenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate

Sources & evidence

ORD record
ord-b910707a02d34d92881e2311d06fb806
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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