Acetic Acid → HCID 178503568, compound

HRID 232559Notes

Reaction equation

HRID 232559 reaction equation
[S:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[N:4][NH:3]1.CI.[C:11](O)(=O)C>[OH-].[Na+]>[CH3:11][S:1][C:2]1[NH:3][N:4]=[CH:5][C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 12759763,4-Dihydro-3-thioxo-1,2,4-triazin-5(2H)-one

Product 1

HCID 178503568HCID 178503568, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Compound 14a (62 g) dissolved in 2N sodium hydroxide (480 ml) is treated with a solution of methyl iodide (30 ml). After 2 hours at room temperature with agitation, the acetic acid (36 ml) is added drop by drop and the mixture set aside overnight at 0° C. The precipitate formed is filtered, centrifuged, and dried under vacuum at 60° C. in the presence of P2O5 in order to obtain the compound 14b (56.4 g).

Workup

  1. waitthe mixture set aside overnight at 0° C
  2. customThe precipitate formed
  3. filtrationis filtered
  4. dry with materialdried under vacuum at 60° C. in the presence of P2O5 in order

Sources & evidence

ORD record
ord-f98bf9984f1f4176a8593f56e7ffc1fd
Source dataset
uspto-grants-1997_01
Patent number
US05591743

Reaction notes

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