2-Ethoxybenzoyl chloride → 4-Cyano-3-(2-ethoxybenzylamino)pyridine-2-carboxamide

HRID 232573Notes

Reaction equation

HRID 232573 reaction equation
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=O)[CH3:2].[NH2:13][C:14]1[C:15]([C:22]([NH2:24])=[O:23])=[N:16][CH:17]=[CH:18][C:19]=1[C:20]#[N:21]>>[C:20]([C:19]1[CH:18]=[CH:17][N:16]=[C:15]([C:22]([NH2:24])=[O:23])[C:14]=1[NH:13][CH2:6][C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[O:3][CH2:1][CH3:2])#[N:21]

Participants

3

Reactant 2

HCID 30163972-Ethoxybenzoyl chlorideHCID 224624043-Amino-4-cyanopyridine-2-carboxamide

Product 1

HCID 233589904-Cyano-3-(2-ethoxybenzylamino)pyridine-2-carboxamide

Procedure

The title compound was prepared from 2-ethoxybenzoyl chloride and 3-amino-4-cyanopyridine-2-carboxamide (Preparation 12), following the procedure of Preparation 7, and was obtained as a colourless solid. (6.2%), m.p. 150°-152° C. Found: C,61.99; H,4.62; N,17.84. C16H14N4O3 requires C,61.93; H,4.55; N,18.06%.

Workup

  1. customthe procedure of Preparation 7
  2. customwas obtained as a colourless solid

Sources & evidence

ORD record
ord-35681905909448cfb407157f4d6fb33b
Source dataset
uspto-grants-1997_01
Patent number
US05591742

Reaction notes

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