反应详情

To a suspension of 0.380 gm of lithium aluminum hydride in 15 ml of dry tetrahydrofuran is carefully added a solution of the D-proline amide (prepared in B above) in 10 ml tetrahydrofuran. The mixture is refluxed for 2 hrs then cooled and quenched with 2 ml of 2.5N sodium hydroxide. The mixture is filtered through a pad of sodium sulfate and the filter cake washed with 2×50 ml of ether. The combined filtrates are concentrated in vacuo to yield 0.80 gm of desired 2-(1-pyrrolidinylmethyl) pyrrolidine.

1. temperatureThe mixture is refluxed for 2 hrs
2. temperaturethen cooled
3. customquenched with 2 ml of 2.5N sodium hydroxide
4. filtrationThe mixture is filtered through a pad of sodium sulfate
5. washthe filter cake washed with 2×50 ml of ether
6. concentrationThe combined filtrates are concentrated in vacuo