Dichloromethane → 3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one

HRID 2325902Notes

Reaction equation

HRID 2325902 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:18]3[c:19](-[c:30]4[cH:31][cH:32][cH:33][cH:34][cH:35]4)[o:20][c:21]4[cH:22][cH:23][c:24]([F:29])[cH:25][c:26]4[c:27]3=[O:28])[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1)([CH3:5])([CH3:6])[CH3:36].[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[NH2:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:18]3[c:19](-[c:30]4[cH:31][cH:32][cH:33][cH:34][cH:35]4)[o:20][c:21]4[cH:22][cH:23][c:24]([F:29])[cH:25][c:26]4[c:27]3=[O:28])[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67067635{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Product 1

HCID 510305983-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one

Sources & evidence

ORD record
ord-732c3123ea264028a4e60a904f9bc781
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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