Dichloromethane → tert-Butyl 4-(4-amino-3-bromophenyl)-piperidine-1-carboxylate

HRID 2326069Notes

Reaction equation

HRID 2326069 reaction equation
[Br:21][N:22]1[C:23](=[O:24])[CH2:25][CH2:26][C:27]1=[O:28].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([NH2:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:32][CH2:33][O:34][C:35]([CH3:36])=[O:37].[Cl:29][CH2:30][Cl:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][c:16]([Br:21])[c:17]([NH2:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 67184N-bromobutanimideHCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylate

Product 1

HCID 56834849tert-Butyl 4-(4-amino-3-bromophenyl)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-48b9bdd597b24d48a88a6920802a0362
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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