Acetone → t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate

HRID 2326751Notes

Reaction equation

HRID 2326751 reaction equation
[Br:38][CH2:39][C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46].[C:32](=[O:33])([O-:34])[O-:35].[CH3:47][C:48](=[O:49])[CH3:50].[K+:36].[K+:37].[OH:1][c:2]1[c:3]([CH3:31])[c:4]2[c:9]([c:10]([CH3:13])[c:11]1[CH3:12])[O:8][C:7]([CH3:14])([CH2:15][O:16][c:17]1[cH:18][cH:19][c:20]([CH2:21][CH:22]3[C:23](=[O:28])[NH:24][C:25](=[O:27])[S:26]3)[cH:29][cH:30]1)[CH2:6][CH2:5]2>>[OH:1][c:2]1[c:3]([CH3:31])[c:4]2[c:9]([c:10]([CH3:13])[c:11]1[CH3:12])[O:8][C:7]([CH3:14])([CH2:15][O:16][c:17]1[cH:18][cH:19][c:20]([CH2:21][CH:22]3[C:23](=[O:28])[N:24]([CH2:39][C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[C:25](=[O:27])[S:26]3)[cH:29][cH:30]1)[CH2:6][CH2:5]2

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 5591TroglitazoneHCID 19660Carbonate IonHCID 79177tert-Butyl bromoacetate

Product 1

HCID 19822185t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate

Sources & evidence

ORD record
ord-f138cc98e33448298d348033bc81b968
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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