Hydrochloric Acid → HCID 14651279, compound

HRID 232685Notes

Reaction equation

HRID 232685 reaction equation
C([O:4][CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[C:12]([CH3:20])[C:13]([F:19])=[C:14]([F:18])[C:15]=2[F:17])[C:10](=[O:21])[C:9]([C:22]([O:24]CC)=[O:23])=[CH:8]1)(=O)C.Cl>C(O)(=O)C>[OH:4][CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[C:12]([CH3:20])[C:13]([F:19])=[C:14]([F:18])[C:15]=2[F:17])[C:10](=[O:21])[C:9]([C:22]([OH:24])=[O:23])=[CH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14651276HCID 14651276, compound

Product 1

HCID 14651279HCID 14651279, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Employing ethyl 1-(2-acetyloxyethyl)-5-methyl-6,7,8-trifluoro-l,4-dihydro-4-oxoquinoline-3-carboxylate (5.80 g) and conc. hydrochloric acid: 90% acetic acid (1:4) (100 ml), the procedure of Reference Example 23 is repeated to give 1-(2-hydroxyethyl)-5-methyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (4.04 g), as pale yellow flakes (recrystallized from ethanol), m.p. 244.5°-247° C.

Sources & evidence

ORD record
ord-1231d39369814341941346840854221a
Source dataset
uspto-grants-1997_01
Patent number
US05591744

Reaction notes

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