Sodium Hydroxide → HCID 10987760, compound

HRID 232709Notes

Reaction equation

HRID 232709 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:16]([O:18]CC)=[O:17])[CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2>C(O)C>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:16]([OH:18])=[O:17])[CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10857784HCID 10857784, compound

Product 1

HCID 10987760HCID 10987760, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.09 ml of a 5N aqueous sodium hydroxide solution was added to a suspension of 2.00 g of 8-methoxy-6-ethoxycarbonylcarbostyril in ethanol. The mixture became uniform in about 1 minute. The mixture was stirred at room temperature for 4 days. The resulting precipitate was collected by filtration and dissolved in water. The solution was washed with ethyl acetate, and then was made acidic with concentrated hydrochloric acid with ice-cooling. The resulting precipitate was collected by filtration to obtain 1.62 g of 8-methoxy-6-carboxycarbostyril as a white powder.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. dissolutiondissolved in water
  3. washThe solution was washed with ethyl acetate
  4. temperaturecooling
  5. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-e4ab867f8db14057bca93cfb12741bc2
Source dataset
uspto-grants-1997_01
Patent number
US05591751

Reaction notes

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