Sodium Hydroxide → HCID 10987760, compound

Participants

Reaction Steps

8.09 ml of a 5N aqueous sodium hydroxide solution was added to a suspension of 2.00 g of 8-methoxy-6-ethoxycarbonylcarbostyril in ethanol. The mixture became uniform in about 1 minute. The mixture was stirred at room temperature for 4 days. The resulting precipitate was collected by filtration and dissolved in water. The solution was washed with ethyl acetate, and then was made acidic with concentrated hydrochloric acid with ice-cooling. The resulting precipitate was collected by filtration to obtain 1.62 g of 8-methoxy-6-carboxycarbostyril as a white powder.

Provenance & Evidence