Chlorotrimethylsilane → Methyl 3-{[methyl(propyl)amino]carbonyl}-5-(1,3-thiazol-2-yl)benzoate
Reaction equation
[Br:10][c:11]1[s:12][cH:13][cH:14][n:15]1.[Br:1][CH2:2][CH2:3][Br:4].[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:16][O:17][C:18]([c:19]1[cH:20][c:21]([C:22](=[O:23])[N:24]([CH2:25][CH2:26][CH3:27])[CH3:28])[cH:29][c:30]([I:32])[cH:31]1)=[O:33].[Cl:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[Zn:39].[cH:40]1[cH:41][cH:42][c:43]([P:44]([Pd:45]([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)([P:65]([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)([c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[P:84]([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)([c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)[c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)[cH:115][cH:116]1>>[c:11]1(-[c:30]2[cH:29][c:21]([C:22](=[O:23])[N:24]([CH2:25][CH2:26][CH3:27])[CH3:28])[cH:20][c:19]([C:18]([O:17][CH3:16])=[O:33])[cH:31]2)[s:12][cH:13][cH:14][n:15]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-ff19ec76e0e048918a92d5f0ad0d8253
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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