1,4-Dioxa-8-azaspiro(4.5)decane → HCID 67684285, compound

HRID 232768Notes

Reaction equation

HRID 232768 reaction equation
[O:1]1[C@H:3]2[CH2:4][C@H:5]3[C@:18]([CH3:20])([CH2:19][C@@H:2]12)[C@@H:17]1[C@H:8]([C@H:9]2[C@@:13]([CH2:15][CH2:16]1)([CH3:14])[C@@H:12]([OH:21])[C@@H:11]([N:22]1[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]1)[CH2:10]2)[CH2:7][CH2:6]3.[O:29]1[C:33]2([CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[O:32][CH2:31][CH2:30]1>>[O:29]1[C:33]2([CH2:38][CH2:37][N:36]([C@H:2]3[CH2:19][C@@:18]4([CH3:20])[C@@H:5]([CH2:6][CH2:7][C@@H:8]5[C@@H:17]4[CH2:16][CH2:15][C@@:13]4([CH3:14])[C@H:9]5[CH2:10][C@H:11]([N:22]5[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]5)[C@@H:12]4[OH:21])[CH2:4][C@@H:3]3[OH:1])[CH2:35][CH2:34]2)[O:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 86735970HCID 86735970, compound

Product 1

HCID 67684285HCID 67684285, compoundYield 72.34%

Procedure

2α,3α-Epoxy-17β-hydroxy-16β-(4-methyl-1-piperazinyl)-5α-androstane is reacted with 1,4-dioxa-8-azaspiro[4.5]decane as described in Example 3 to give the title compound in a yield of 72.34%, m.p.: 185°-187° C.

Sources & evidence

ORD record
ord-4e48ed73c1b04dec93a0bec93503b3d3
Source dataset
uspto-grants-1997_01
Patent number
US05591735

Reaction notes

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