Piperidine → HCID 67684209, compound

HRID 232772Notes

Reaction equation

[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C@H:11]3[CH2:16][C@H:15]4[C@H:17]5[C@H:27]([CH2:28][CH2:29][C@:13]4([CH3:14])[C@H:12]3[OH:31])[C@:25]3([CH3:26])[C@H:20]([CH2:21][C@@H:22]4[O:30][C@@H:23]4[CH2:24]3)[CH2:19][CH2:18]5)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[NH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[O:1]1[C:5]2([CH2:6][CH2:7][N:8]([C@H:11]3[CH2:16][C@H:15]4[C@H:17]5[C@H:27]([CH2:28][CH2:29][C@:13]4([CH3:14])[C@H:12]3[OH:31])[C@:25]3([CH3:26])[C@H:20]([CH2:21][C@H:22]([OH:30])[C@@H:23]([N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[CH2:24]3)[CH2:19][CH2:18]5)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 8082Piperidine

HCID 86750121HCID 86750121, compound

Product 1

HCID 67684209HCID 67684209, compoundYield 87.5%

Procedure

16β-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2α,3α-epoxy-5α-androstane-17β-ol is reacted with piperidine as described in Example 3 to give the title compound in a yield of 87.5%, m.p.: 183°-185° C.

Sources & evidence

ORD record: ord-1835826313b84564a6804303056411c9
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591735

Reaction notes

Loading…