Piperidin-4-ol → HCID 67684327, compound

HRID 232774Notes

Reaction equation

HRID 232774 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C@H:11]3[CH2:16][C@H:15]4[C@H:17]5[C@H:27]([CH2:28][CH2:29][C@:13]4([CH3:14])[C@H:12]3[OH:31])[C@:25]3([CH3:26])[C@H:20]([CH2:21][C@@H:22]4[O:30][C@@H:23]4[CH2:24]3)[CH2:19][CH2:18]5)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[OH:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C@H:11]3[CH2:16][C@H:15]4[C@H:17]5[C@H:27]([CH2:28][CH2:29][C@:13]4([CH3:14])[C@H:12]3[OH:31])[C@:25]3([CH3:26])[C@H:20]([CH2:21][C@H:22]([OH:30])[C@@H:23]([N:36]4[CH2:37][CH2:38][CH:33]([OH:32])[CH2:34][CH2:35]4)[CH2:24]3)[CH2:19][CH2:18]5)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 86750121HCID 86750121, compound

Product 1

HCID 67684327HCID 67684327, compoundYield 78.3%

Procedure

16β-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2α,3α-epoxy-17β-hydroxy-5α-androstane is reacted with 4-hydroxypiperidine as described in Example 3 to obtain the title compound in a yield of 78.3%, m.p.: 199°-201° C.

Sources & evidence

ORD record
ord-2367ca06f65d46789a7e1b5273957086
Source dataset
uspto-grants-1997_01
Patent number
US05591735

Reaction notes

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