Diisopropylamine → 4-Tert-butyl 1-methyl 2-(4-chlorobenzyl)succinate

HRID 2327848Notes

Reaction equation

HRID 2327848 reaction equation
[Br:26][CH2:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[CH:6]([NH:7][CH:8]([CH3:9])[CH3:10])([CH3:11])[CH3:12].[Cl:13][c:14]1[cH:15][cH:16][c:17]([CH2:20][CH2:21][C:22](=[O:23])[O:24][CH3:25])[cH:18][cH:19]1>>[Cl:13][c:14]1[cH:15][cH:16][c:17]([CH2:20][CH:21]([C:22](=[O:23])[O:24][CH3:25])[CH2:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[cH:18][cH:19]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 79177tert-Butyl bromoacetateHCID 8027172Methyl 3-(4-chlorophenyl)propanoateHCID 178418339Butyllithium

Product 1

HCID 687336964-Tert-butyl 1-methyl 2-(4-chlorobenzyl)succinate

Sources & evidence

ORD record
ord-7c5f71c47dfb49709554698832a0be07
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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