反应详情

3α-acetoxy-5α-pregnan-20-one (4.8 g) in 150 mL of methanol was cooled to 0° C. with an ice bath and 15.0 mL of perchloric acid was added dropwise. After 30 m of stirring, the ice bath was removed and the reaction mixture was left stirring for three days. The reaction mixture was poured into water and extracted with chloroform three times. The chloroform extracts were combined, dried over magnesium sulfate, and the solvent evaporated to give 4.57 g of crude product.

1. customthe ice bath was removed
2. waitthe reaction mixture was left
3. stirringstirring for three days
4. additionThe reaction mixture was poured into water
5. extractionextracted with chloroform three times
6. dry with materialdried over magnesium sulfate
7. customthe solvent evaporated