Methyl (2-aminoindan-5-yl)acetate hydrochloride → 2-Aminoindane-5-acetic acid hydrochloride

HRID 232820Notes

Reaction equation

HRID 232820 reaction equation
[ClH:1].[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[CH:9]=2)[CH2:4]1>Cl>[ClH:1].[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=2)[CH2:4]1

Participants

3

Reactant 1

HCID 23359670Methyl (2-aminoindan-5-yl)acetate hydrochloride

Product 1

HCID 677154512-Aminoindane-5-acetic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3.6 g of methyl 2-aminoindane-5-acetatehydrochloride are refluxed for 3 hours in 160 ml of semiconcentrated hydrochloric acid. The hydrochloric acid is distilled off and the remaining product is triturated with a little ethanol, suction filtered and dried in vacuo.

Workup

  1. distillationThe hydrochloric acid is distilled off
  2. customthe remaining product is triturated with a little ethanol, suction
  3. filtrationfiltered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-9ad09ef9d76a46ef9b8d69b40e8a8f64
Source dataset
uspto-grants-1997_01
Patent number
US05591769

Reaction notes

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