N-(gamma-Maleimidobutyryloxy)succinimide → HCID 86750125, compound

HRID 232825Notes

Reaction equation

HRID 232825 reaction equation
[CH2:1]([N:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])[CH2:2][N:3]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][C:5]([OH:7])=[O:6].[CH2:21]([NH:28][NH:29][C:30]([NH:32][NH2:33])=[S:31])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[C:34]1(=[O:53])[N:38]([CH2:39][CH2:40][CH2:41][C:42](ON2C(=O)CCC2=O)=[O:43])[C:37](=[O:52])[CH:36]=[CH:35]1>CN(C)C=O>[CH2:2]([N:3]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][C:5]([OH:7])=[O:6])[CH2:1][N:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15].[CH2:21]([N:28]([C:42](=[O:43])[CH2:41][CH2:40][CH2:39][N:38]1[C:37](=[O:52])[CH:36]=[CH:35][C:34]1=[O:53])[NH:29][C:30]([NH:32][NH2:33])=[S:31])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 133440N-(gamma-Maleimidobutyryloxy)succinimideHCID 86750127HCID 86750127, compound

Product 1

HCID 86750125HCID 86750125, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The EDTA-benzylthiocarbazide prepared in step 1 (20 mg; 34 μmol) and N-(gamma-maleimidobutyryloxy)succinimide (8 mg, 29 μmol=0.9 equiv.) were stirred in anhydrous dimethylformamide for 1 h. The mixture was then evaporated to dryness, and the residue was dried under high vacuum.

Workup

  1. customThe mixture was then evaporated to dryness
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-1f79f3bbcd424b1e8ed7f3e878d5475f
Source dataset
uspto-grants-1997_01
Patent number
US05591828

Reaction notes

Loading…