Dimethylformamide → N-(5-bromopyrazin-2-yl)-3-cyclopentyl-2-[3-oxo-7-(trifluoromethyl)-1H-isoindol-2-yl]propanamide

HRID 2328588노트

반응식

[Br:31][c:32]1[n:33][cH:34][c:35]([NH2:38])[n:36][cH:37]1.[CH2:47]([Cl:48])[Cl:49].[CH3:50][N:51]([CH3:52])[CH:53]=[O:54].[CH:1]1([CH2:6][CH:7]([C:8](=[O:9])[OH:10])[N:11]2[C:12](=[O:24])[c:13]3[cH:14][cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[c:18]3[CH2:19]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:25][C:26]([C:27]([Cl:28])=[O:29])=[O:30].[n:39]1[c:40]([CH3:41])[cH:42][cH:43][cH:44][c:45]1[CH3:46]>>[CH:1]1([CH2:6][CH:7]([C:8](=[O:10])[NH:38][c:35]2[cH:34][n:33][c:32]([Br:31])[cH:37][n:36]2)[N:11]2[C:12](=[O:24])[c:13]3[cH:14][cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[c:18]3[CH2:19]2)[CH2:2][CH2:3][CH2:4][CH2:5]1