反应详情

Under ice cooling and stirring, 1.5 g of sodium nitrite dissolved in 2 ml of water was added dropwise over 1.5 hours to 3 g of 3-amino-o-toluic acid dissolved in a mixed solution of 8 ml of acetic acid, 8.3 g of sulfuric acid and 6.5 ml of water. After 3.2 ml of acetic acid, 0.4 g of sulfuric acid and 5.6 ml of water were added to the reaction mixture, the mixture was filtered and the reaction filtrate was adjusted. On the other hand, 6.5 g of potassium cyanide dissolved in 12.7 ml of water was added dropwise to 5.9 g of copper sulfate.pentahydrate dissolved in 12.7 ml of water at room temperature under stirring and 21.5 g of sodium hydrogen carbonate and 70 ml of toluene were added to the mixture. Under ice cooling and stirring, the above reaction filtrate was added dropwise to this 10 reaction mixture over 1 hour and then the mixture was stirred at 80° C. for 30 minutes. After completion of the reaction, the reaction mixture was adjusted to about pH 3 with 1N-hydrochloric acid, crystals precipitated were extracted with ethyl acetate and the organic layer was washed with a saturated saline solution and then dried over anhydrous sodium carbonate. The solvent was removed to obtain 3.8 g of the title compound. Mass (CI); m/z=162 (M+ +1)

1. filtrationthe mixture was filtered
2. dissolutionOn the other hand, 6.5 g of potassium cyanide dissolved in 12.7 ml of water
3. additionwas added dropwise to 5.9 g of copper sulfate
4. dissolutionpentahydrate dissolved in 12.7 ml of water at room temperature
5. stirringunder stirring
6. addition21.5 g of sodium hydrogen carbonate and 70 ml of toluene were added to the mixture
7. stirringUnder ice cooling and stirring
8. additionthe above reaction filtrate was added dropwise to this 10 reaction mixture over 1 hour
9. stirringthe mixture was stirred at 80° C. for 30 minutes
10. customAfter completion of the reaction
11. customprecipitated
12. extractionwere extracted with ethyl acetate
13. washthe organic layer was washed with a saturated saline solution
14. dry with materialdried over anhydrous sodium carbonate
15. customThe solvent was removed