反应详情

12.6 g of a 28% sodium methylate methanol solution and 4.2 g of copper iodide were added to 5 g of methyl 4-bromo-toluate dissolved in 20 ml of dimethylformamide and the mixture was refluxed under heating for 2 hours. The reaction mixture was adjusted to about pH 2 by adding 1N-hydrochloric acid thereto and extracted with ethyl acetate. and the organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. The residue obtained by removing the solvent was applied to silica gel column chromatography to obtain 2.47 g of the title compound.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 2 hours
3. extractionextracted with ethyl acetate
4. washand the organic layer was washed with a saturated saline solution
5. dry with materialdried over anhydrous sodium sulfate
6. customThe residue obtained
7. customby removing the solvent