HCID 54008131, compound → HCID 54425397, compound

HRID 232888Notes

Reaction equation

HRID 232888 reaction equation
C(OC([N:11]([C:17]1([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18]1)[C:12](=[O:16])[CH2:13][NH:14][CH3:15])=O)C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:15][NH:14][CH2:13][C:12]([NH:11][C:17]1([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18]1)=[O:16]

Participants

4

Reactant 1

HCID 54008131HCID 54008131, compound

Product 1

HCID 54425397HCID 54425397, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl 2-(N-benzyloxycarbonyl-N-methylaminoacetylamino)tetralin-2-carboxylate (750 mg, 1.8 mmol) in ethanol (20 ml) was subjected to hydrogenation in the presence of 10% palladium-carbon (200 mg) for 5 hours. After the catalyst was filtered off, the mother liquid was concentrated under reduced pressure to yield 500 mg (96%) of the title compound as a crude substance.

Workup

  1. filtrationAfter the catalyst was filtered off
  2. concentrationthe mother liquid was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5e3c247104b145368049a7d6c9840a12
Source dataset
uspto-grants-1997_01
Patent number
US05591849

Reaction notes

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