3,4-Dichlorobenzaldehyde → (7bR,11aS)-N-(3,4-dichlorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine

Participants

Role	Name	HCID	Charge
Reactant	3,4-Dichlorobenzaldehyde	HCID 22710	—
Reactant	tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H) carboxylate	HCID 86586437	—
Product	(7bR,11aS)-N-(3,4-dichlorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine	HCID 60071820	—

Reaction Steps

Using 3,4-dichlorobenzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H)-carboxylate from EXAMPLE 33, Part B was converted into the title compound of EXAMPLE 158. LRMS (ES)+: 420.4 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06849619B2
Source dataset	uspto-grants-2005_02
ORD ID	ord-edf3685051e245feb87d41c22f43555a
Source note	uspto-grants-2005_02