Ammonia → 2-Chloropyrimidine-4-carboxyamide

Temperature

10 °C

Ammonia gas was introduced in 20 ml of tetrahydrofuran at -6° C. for 35 minutes. Then it was heated to 10° C. and 1.5 g (8.47 mmol) of 2-chloropyrimidine-4-carboxylic acid chloride was added. The reaction solution was stirred for 45 minutes at room temperature. Then it was concentrated by evaporation on a rotary evaporator, the residue was poured on 90 ml of saturated NaHCO3 solution, and the aqueous phase was extracted three times with 50 ml of ethyl acetate each. The combined organic phase was washed with saturated NaCl solution, dried on Na2SO4 and concentrated by evaporation on a ratory evaporator. After drying on a high vacuum, 1.07 g of product was obtained as a white solid, corresponding to a yield of 80 percent relative to the 2-chloropyrimidine-4-carboxylic acid chloride used. The melting point of the product was 147.2° to 151.4° C. Other data of the product was:

1. concentrationThen it was concentrated by evaporation on a rotary evaporator
2. additionthe residue was poured on 90 ml of saturated NaHCO3 solution
3. extractionthe aqueous phase was extracted three times with 50 ml of ethyl acetate each
4. washThe combined organic phase was washed with saturated NaCl solution
5. customdried on Na2SO4
6. concentrationconcentrated by evaporation on a ratory evaporator
7. customAfter drying on a high vacuum

ORD record

ord-dba9701cee4a424ab2b1e68790e8e604

Source dataset

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05591853