Triphenylphosphine → 2-amino-4-(1,1-difluoro-ethyl)-5-(2-isopropyl-2H-pyrazol-3-yl)-benzoic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3]([c:4]1[c:5]([NH2:15])[cH:6][c:7]([C:11]([CH3:12])([F:13])[F:14])[c:8]([I:10])[cH:9]1)=[O:16].[CH:17]([CH3:18])([CH3:19])[n:20]1[n:21][cH:22][cH:23][c:24]1[Sn:25]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37].[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1.[Pd:44]([Cl:45])[Cl:46].[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1.[c:66]1([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81][cH:82][cH:83][cH:84]1>>[CH3:1][O:2][C:3]([c:4]1[c:5]([NH2:15])[cH:6][c:7]([C:11]([CH3:12])([F:13])[F:14])[c:8](-[c:24]2[n:20]([CH:17]([CH3:18])[CH3:19])[n:21][cH:22][cH:23]2)[cH:9]1)=[O:16]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-dad3bf6b042c4a4981a9c63af453588e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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