Trifluoroacetic acid → HCID 19964663, compound

HRID 232974Notes

Reaction equation

HRID 232974 reaction equation
[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([O:24]C(C)(C)C)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:29]=[C:30]([C:33]3[N:34]=[CH:35][N:36]([CH:38]([CH3:40])[CH3:39])[CH:37]=3)[CH:31]=[CH:32][C:6]=2[N:5]=1)[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[C:17]([C:22]([OH:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:14][CH:15]=2)[C:7]2[CH:29]=[C:30]([C:33]3[N:34]=[CH:35][N:36]([CH:38]([CH3:39])[CH3:40])[CH:37]=3)[CH:31]=[CH:32][C:6]=2[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67708456HCID 67708456, compound

Product 1

HCID 19964663HCID 19964663, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 88 from tert.butyl 4'-[(2-ethoxy-6-(1-isopropyl-imidazol-4-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylate and trifluoroacetic acid in methylene chloride.

Sources & evidence

ORD record
ord-66b576e5f3c54e64b2bb6d47b7200a88
Source dataset
uspto-grants-1997_01
Patent number
US05591762

Reaction notes

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