5-(2-Nitrobenzoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-pyrazole → 5-(2-Aminobenzoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-pyrazole

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Reaction Steps

The mixture of pyrazoles of examples 13C and 13D (2.35 g, 6.772 mmol) was taken up in dry THF (100 ml) and degassed. 5% Pd.-on-carbon (1.2 g) was added and the mixture hydrogenated at 30 psi and ambient temperature for 2 h. The mixture was filtered (celite filter aid) and evaporated and then chromatographed (eluant 30% EtOAc in hexanes) to provide the two tide compounds as an equimolar mixture (1.05 g, 49%).

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